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LC–MS in Host Cell Protein (HCP) Analysis:
From Total to Protein-Level Insight 

 Move beyond total HCP measurement and gain deeper, protein-level insight
to support risk-based decision-making in biopharmaceutical development. 

 

 📅 May 12

🕒 3:00 PM (CEST) | 9:00 AM (EDT) 

 

Overview

While ELISA remains the standard for HCP monitoring in QC environments, its reliance on total HCP measurement limits visibility into individual high-risk or persistent impurities. As analytical expectations continue to evolve, this creates a clear need for more detailed, protein-level insight to support informed decision-making in biopharmaceutical development.

In this webinar, our experts Oliwia Bocheńska together with Antonietta Carbone, will guide you through the shift from conventional approaches to LC–MS-based HCP.

During this session, we will explore key questions such as:

  • What are the limitations of relying solely on total HCP measurements?
  • What changes when you are moving from total quantification to protein-level analysis?
  • What is the role of LC–MS in supporting process development, downstream processing, and batch comparability studies?

The webinar will conclude with a live Q&A session, giving you the opportunity to ask questions directly to our experts and discuss your specific analytical challenges.

By combining scientific depth with real-world application, this webinar demonstrates how LC–MS can complement existing analytical approaches and provide actionable insight for more robust, risk-based HCP monitoring strategies.

 

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Register for Webinar!

Selvita Experts

Meet Our Speakers

Oliwia BJPG

Oliwia Bocheńska

Lead Analytical Expert

Oliwia Bocheńska specializes in mass spectrometry–based protein characterization, supporting biologics development through advanced analytical strategies.

With over 17 years of experience across academia and industry, she leads complex projects in biologics and oligonucleotide analysis, with a strong focus on LC–MS method development in GLP and GMP environments.

She holds a PhD in biochemistry from Jagiellonian University.

Antonietta

Antonietta Carbone

Business Development Director

Antonietta Carbone is Business Development Director at Selvita. With a background in biology, she works closely with pharmaceutical and biotech clients, supporting development, analytical and CMC projects across small molecules, peptides and biologics.

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